DEVELOPMENT OF A SOLID DOSAGE FORM WITH ADSORPTION ACTIVITY

Formulation Development of Solid Oral Dosage Form

6.1 Literature review matrix Taha E. et al (2015) evaluated Diclofenac Sodium (DS) matrix tablets prepared by direct compression method under different compression forces using ethyl cellulose as matrix forming material. The produced tablets were characterized for hardness, friability, drug content, weight variations and in vitro drug release. Incompatibility study carried out using DSC FT-IR s...

Solubility enhancement of glimperide: Development of solid dispersion by solvent melt method, characterization and dosage form development

The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...

Advances in solid dosage form manufacturing technology.

Currently, the pharmaceutical and healthcare industries are moving through a period of unparalleled change. Major multinational pharmaceutical companies are restructuring, consolidating, merging and more importantly critically assessing their competitiveness to ensure constant growth in an ever-more demanding market where the cost of developing novel products is continuously increasing. The pha...

Development, optimization and evaluation of solid dosage form of Thiocolchicoside by using absorption enhancers

Thiocolchicoside has a selective affinity for g-amino-butyric acid (GABA) receptors and acts on themuscular contracture by activating the GABA-nergicinhibitory pathways thereby acting as a potent muscle relaxant Thiocolchicoside (Muscoril, Myoril, Neoflax) is a muscle relaxant with anti-inflammatory and analgesic effects. It is used for the treatment of orthopedic, traumatic and rheumatologic d...

NIR prediction of solid dosage form dissolution profile